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Trabectedin

CHEMBL450449 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
761.8 g/mol
LogP
3.4
Phase
4

Trabectedin (ecteinascidin-743, ET-743) is a marine-derived tetrahydroisoquinoline alkaloid that binds to the minor groove of DNA, distorting the DNA helix, stalling RNA polymerase II, and triggering nucleotide excision repair machinery to generate lethal double-strand breaks preferentially in actively transcribed genes. It is approved for unresectable soft tissue sarcoma and relapsed ovarian cancer (in combination with pegylated liposomal doxorubicin), and is under investigation for other malignancies. Its unique mechanism of action in transcription-coupled repair makes it active in tumors with deficient homologous recombination.

Khối lượng phân tử

761,8000 g/mol

LogP

3,40

TPSA

194,00 Ų

Lipinski RO5

Không đạt

Lĩnh vực điều trị

Ovarian Cancer Pancreatic Cancer Lymphoma Prostate Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
COc1cc2c(cc1O)CCN[C@]21CS[C@@H]2c3c(OC(C)=O)c(C)c4c(c3[C@H](COC1=O)N1[C@@H]2[C@H]2c3c(cc(C)c(OC)c3O)C[C@@H]([C@@H]1O)N2C)OCO4

                

                

                
                

                    
InChI

                    
InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C39H43N3O11S

                    

                    
                    

                        
HBD / HBA

                        
4 / 15

                    

                    
                    

                        
Liên kết có thể quay

                        
4

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
54

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Trabectedin (ecteinascidin-743, ET-743) is a marine-derived tetrahydroisoquinoline alkaloid that binds to the minor groove of DNA, distorting the DNA helix, stalling RNA polymerase II, and triggering nucleotide excision repair machinery to generate lethal double-strand breaks preferentially in actively transcribed genes. It is approved for unresectable soft tissue sarcoma and relapsed ovarian cancer (in combination with pegylated liposomal doxorubicin), and is under investigation for other malignancies. Its unique mechanism of action in transcription-coupled repair makes it active in tumors with deficient …

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Trabectedin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL450449.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 108150.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.