Plasma Protein Binding Displacement

A pharmacokinetic interaction in which one drug displaces another from plasma protein binding sites (primarily albumin or alpha-1-acid glycoprotein), transiently increasing the free fraction of the displaced drug. Clinically significant displacement occurs mainly with highly protein-bound drugs that have a narrow therapeutic index and small volume of distribution.

Ví dụ

• Valproic acid displacing phenytoin from albumin, raising free phenytoin levels
• Sulfonamides displacing bilirubin from albumin in neonates (kernicterus risk)
• Warfarin displacement by NSAIDs increasing free warfarin and bleeding risk