Tumor Necrosis Factor (TNF)

TNF
Immunopharmacology

A pro-inflammatory cytokine primarily produced by activated macrophages that plays a central role in systemic inflammation, apoptosis, and immune cell regulation. TNF-alpha signals through TNFR1 (ubiquitous) and TNFR2 (immune cells). Excessive TNF-alpha drives chronic inflammatory diseases, making it a major therapeutic target.

Ví dụ

  • Infliximab — chimeric anti-TNF mAb (Crohn's, ulcerative colitis)
  • Etanercept — soluble TNF receptor fusion protein (rheumatoid arthritis)
  • Adalimumab — fully human anti-TNF mAb (best-selling biologic drug)

Bạn có biết không?

A pro-inflammatory cytokine primarily produced by activated macrophages that plays a central role in systemic inflammation, apoptosis, and immune cell regulation. TNF-alpha signals through TNFR1 (ubiquitous) and TNFR2 (immune cells). …