Vaccine Adjuvant
A substance added to a vaccine formulation that enhances the magnitude, breadth, or durability of the immune response to the antigen without being immunogenic itself. Adjuvants work by activating innate immune pathways (TLRs, inflammasome), creating antigen depots, or recruiting antigen-presenting cells. They are essential for subunit and inactivated vaccines that are poorly immunogenic alone.
Ví dụ
- Alum (aluminum salts) — most widely used adjuvant since 1926
- AS04 (alum + MPL) — used in Cervarix HPV vaccine
- MF59 (squalene emulsion) — used in Fluad influenza vaccine
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A substance added to a vaccine formulation that enhances the magnitude, breadth, or durability of the immune response to the antigen without being immunogenic itself. Adjuvants work by activating innate …