Major
Established
Mô tả
Combining two SSRIs is generally contraindicated due to markedly elevated serotonin syndrome risk and no additional therapeutic benefit.
Cơ chế
Both agents inhibit SERT-mediated serotonin reuptake; concurrent use produces additive serotonin accumulation in central synapses.
Ý nghĩa lâm sàng
Dual SSRI therapy provides no clinical advantage over monotherapy and substantially raises serotonin toxicity risk.
Xử trí
Avoid concurrent use; when switching SSRIs, allow an appropriate washout period (5 half-lives of the discontinued drug).