Brinzolamide
A carbonic anhydrase inhibitor used as eye drops to lower elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It works by reducing the production of aqueous humor inside the eye. It is often used in combination with other eye pressure-lowering drops.
分子量
383.5000 g/mol
LogP
-0.30
TPSA
164.00 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
二维结构
Cite this structure
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SMILES
CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(S(N)(=O)=O)cc21
InChI
InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
Molecular Formula
C12H21N3O5S3
HBD / HBA
2 / 9
可旋转键数
7
重原子数
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A carbonic anhydrase inhibitor used as eye drops to lower elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It works by reducing the production of aqueous humor inside the eye. It is often used in combination with other eye pressure-lowering drops.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Brinzolamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL220491. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 68844. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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