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Captopril

CHEMBL1560 Phase 4 已批准 Small molecule
Half-Life
1.9 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
217.3 g/mol
LogP
0.3
Phase
4

The first orally active ACE inhibitor, used to treat hypertension, heart failure, and to protect kidney function in diabetic nephropathy. By blocking the angiotensin-converting enzyme, it prevents the formation of angiotensin II, leading to blood vessel relaxation and reduced aldosterone secretion. A dry persistent cough is a characteristic and common side effect.

分子量

217.2850 g/mol

LogP

0.30

TPSA

58.60 Ų

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Chronic Kidney Disease Stroke Obesity Type 2 Diabetes Hypertension Breast Cancer Heart Failure Atrial Fibrillation Prostate Cancer Colorectal Cancer Leukemia

药物分类

C — C - Cardiovascular System

作用机制

First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Pharmacokinetics (PK)

Half-Life 1.9 hours

Pharmacodynamics (PD)

机制

First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

二维结构

SVG PNG

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SMILES

                    
C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C9H15NO3S

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
可旋转键数

                        
3

                    

                    
                    
                    

                        
重原子数

                        
14

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
The first orally active ACE inhibitor, used to treat hypertension, heart failure, and to protect kidney function in diabetic nephropathy. By blocking the angiotensin-converting enzyme, it prevents the formation of angiotensin II, leading to blood vessel relaxation and reduced aldosterone secretion. A dry persistent cough is a characteristic and common side effect.

                        

                    

                    

                    

                    
                    

                        
                        

                            
First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Captopril: Half-life: 1.9 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Captopril is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Atorvastatin
                            Small molecule
                        
                        
                        
                            Amlodipine
                            Small molecule
                        
                        
                        
                            Lisinopril
                            Small molecule
                        
                        
                        
                            Metoprolol
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1560.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 44093.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.