Metoprolol
This beta-blocker slows the heart rate and reduces the heart's workload by blocking the effects of adrenaline. It is prescribed for conditions such as high blood pressure, irregular heart rhythms, and heart failure.
分子量
267.3640 g/mol
LogP
1.90
TPSA
50.70 Ų
Lipinski 五规则
符合
治疗领域
药物分类
作用机制
Selective beta-1 adrenergic receptor blocker.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selective beta-1 adrenergic receptor blocker.
二维结构
Cite this structure
Embed this structure
SMILES
COCCc1ccc(OCC(O)CNC(C)C)cc1
InChI
InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
Molecular Formula
C15H25NO3
HBD / HBA
2 / 4
可旋转键数
9
重原子数
19
Tacrolimus may mildly prolong the QT interval; metoprolol's bradycardic effect may compound this modestly, though clinically significant arrhythmia is uncommon at standard doses.
Diltiazem combined with metoprolol increases the risk of bradycardia and AV block through additive negative chronotropic and dromotropic effects.
Metoprolol adds to digoxin's rate-slowing effect at the AV node, increasing the risk of bradycardia and AV block in susceptible patients.
Beta-blockers such as metoprolol mask the adrenergic warning symptoms of hypoglycaemia (tachycardia, tremor) and may prolong hypoglycaemic episodes in insulin-treated patients.
Bupropion is a potent CYP2D6 inhibitor that substantially increases metoprolol plasma concentrations, potentially causing excessive beta-blockade (bradycardia, hypotension, heart block).
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This beta-blocker slows the heart rate and reduces the heart's workload by blocking the effects of adrenaline. It is prescribed for conditions such as high blood pressure, irregular heart rhythms, and heart failure.
Selective beta-1 adrenergic receptor blocker.
Key pharmacokinetic parameters for Metoprolol: Half-life: 3-7 hours.
Yes, Metoprolol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL13. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4171. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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