Chlophedianol
A centrally acting antitussive agent that suppresses the cough reflex to provide symptomatic relief from nonproductive cough. It is often used in combination with other cough and cold ingredients. It has mild antihistamine and anticholinergic properties in addition to its cough-suppressing activity.
分子量
289.8000 g/mol
LogP
3.60
TPSA
23.50 Ų
Lipinski 五规则
符合
作用机制
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
二维结构
Cite this structure
Embed this structure
SMILES
CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl
InChI
InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3
Molecular Formula
C17H20ClNO
HBD / HBA
1 / 2
可旋转键数
5
重原子数
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A centrally acting antitussive agent that suppresses the cough reflex to provide symptomatic relief from nonproductive cough. It is often used in combination with other cough and cold ingredients. It has mild antihistamine and anticholinergic properties in addition to its cough-suppressing activity.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Chlophedianol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201313. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2795. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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