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Elapegademase

CHEMBL3990026 Phase 4 已批准 Enzyme
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
248.3 g/mol
LogP
-2.7
Phase
4

This enzyme replacement therapy provides a working version of adenosine deaminase, an enzyme missing in a rare form of severe combined immunodeficiency. Regular injections help restore immune system function in affected patients.

分子量

248.2800 g/mol

LogP

-2.70

TPSA

111.00 Ų

Lipinski 五规则

符合

作用机制

Provides exogenous replacement of the deficient or absent enzyme, enabling the metabolic processing of accumulated substrates and restoring normal metabolic function.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Provides exogenous replacement of the deficient or absent enzyme, enabling the metabolic processing of accumulated substrates and restoring normal metabolic function.

二维结构

SVG PNG

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SMILES

                    
COCCOC(=O)NCCCC[C@@H](C(=O)O)N

                

                

                
                

                    
InChI

                    
InChI=1S/C10H20N2O5/c1-16-6-7-17-10(15)12-5-3-2-4-8(11)9(13)14/h8H,2-7,11H2,1H3,(H,12,15)(H,13,14)/t8-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H20N2O5

                    

                    
                    

                        
HBD / HBA

                        
3 / 6

                    

                    
                    

                        
可旋转键数

                        
10

                    

                    
                    
                    

                        
重原子数

                        
17

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This enzyme replacement therapy provides a working version of adenosine deaminase, an enzyme missing in a rare form of severe combined immunodeficiency. Regular injections help restore immune system function in affected patients.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Provides exogenous replacement of the deficient or absent enzyme, enabling the metabolic processing of accumulated substrates and restoring normal metabolic function.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Elapegademase is an approved drug. It has reached clinical phase 4. It is classified as a Enzyme.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3990026.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 121488177.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.