Hydrocodone

CHEMBL1457 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

299.4 g/mol

LogP

2.2

Phase

4

An opioid pain reliever and cough suppressant used to treat moderate to severe pain and to suppress chronic cough, working by binding to opioid receptors in the brain and spinal cord to alter the perception of pain. It is typically formulated in combination with acetaminophen or other non-opioid analgesics. Due to its high potential for dependence and abuse, it is a Schedule II controlled substance requiring careful prescribing.

分子量

299.4000 g/mol

LogP

2.20

TPSA

38.80 Å²

Lipinski 五规则

符合

治疗领域

Pain Management Obesity Lymphoma Breast Cancer Chronic Pain

作用机制

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …

二维结构

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SMILES

COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314

InChI

InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1

Molecular Formula

C18H21NO3

HBD / HBA

- / 4

可旋转键数

1

重原子数

22

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

An opioid pain reliever and cough suppressant used to treat moderate to severe pain and to suppress chronic cough, working by binding to opioid receptors in the brain and spinal cord to alter the perception of pain. It is typically formulated in combination with acetaminophen or other non-opioid analgesics. Due to its high potential for dependence and abuse, it is a Schedule II controlled substance requiring careful prescribing.

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Yes, Hydrocodone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1457. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5284569. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C18H21NO3
同义词: 23

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.