Hydrocodone
An opioid pain reliever and cough suppressant used to treat moderate to severe pain and to suppress chronic cough, working by binding to opioid receptors in the brain and spinal cord to alter the perception of pain. It is typically formulated in combination with acetaminophen or other non-opioid analgesics. Due to its high potential for dependence and abuse, it is a Schedule II controlled substance requiring careful prescribing.
Peso Molecular
299,4000 g/mol
LogP
2,20
TPSA
38,80 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …
Estrutura 2D
Cite this structure
Embed this structure
SMILES
COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
InChI
InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1
Molecular Formula
C18H21NO3
HBD / HBA
- / 4
Ligações Rotacionáveis
1
Átomos Pesados
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
An opioid pain reliever and cough suppressant used to treat moderate to severe pain and to suppress chronic cough, working by binding to opioid receptors in the brain and spinal cord to alter the perception of pain. It is typically formulated in combination with acetaminophen or other non-opioid analgesics. Due to its high potential for dependence and abuse, it is a Schedule II controlled substance requiring careful prescribing.
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Yes, Hydrocodone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1457. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5284569. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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