Piflufolastat F18

CHEMBL4297334 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

441.4 g/mol

LogP

-0.1

Phase

4

Piflufolastat F18 is a fluorine-18 radiolabeled small molecule PSMA-targeted PET imaging agent used for the detection and localization of PSMA-positive lesions in prostate, bladder, and breast cancer staging and restaging. It functions by selectively binding to prostate-specific membrane antigen expressed on tumor cells and tumor neovasculature, enabling precise lesion detection by PET imaging.

分子量

441.4000 g/mol

LogP

-0.10

TPSA

195.00 Å²

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

O=C(O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)c1ccc([18F])nc1)C(=O)O)C(=O)O

InChI

InChI=1S/C18H23FN4O8/c19-13-6-4-10(9-21-13)15(26)20-8-2-1-3-11(16(27)28)22-18(31)23-12(17(29)30)5-7-14(24)25/h4,6,9,11-12H,1-3,5,7-8H2,(H,20,26)(H,24,25)(H,27,28)(H,29,30)(H2,22,23,31)/t11-,12-/m0/s1/i19-1

Molecular Formula

C18H23FN4O8

HBD / HBA

6 / 10

可旋转键数

13

重原子数

31

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

Piflufolastat F18 is a fluorine-18 radiolabeled small molecule PSMA-targeted PET imaging agent used for the detection and localization of PSMA-positive lesions in prostate, bladder, and breast cancer staging and restaging. It functions by selectively binding to prostate-specific membrane antigen expressed on tumor cells and tumor neovasculature, enabling precise lesion detection by PET imaging.

Yes, Piflufolastat F18 is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297334. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 52950901. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C18H23FN4O8

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.