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Piflufolastat F18

CHEMBL4297334 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
441.4 g/mol
LogP
-0.1
Phase
4

Piflufolastat F18 is a fluorine-18 radiolabeled small molecule PSMA-targeted PET imaging agent used for the detection and localization of PSMA-positive lesions in prostate, bladder, and breast cancer staging and restaging. It functions by selectively binding to prostate-specific membrane antigen expressed on tumor cells and tumor neovasculature, enabling precise lesion detection by PET imaging.

Khối lượng phân tử

441,4000 g/mol

LogP

-0,10

TPSA

195,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=C(O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)c1ccc([18F])nc1)C(=O)O)C(=O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C18H23FN4O8/c19-13-6-4-10(9-21-13)15(26)20-8-2-1-3-11(16(27)28)22-18(31)23-12(17(29)30)5-7-14(24)25/h4,6,9,11-12H,1-3,5,7-8H2,(H,20,26)(H,24,25)(H,27,28)(H,29,30)(H2,22,23,31)/t11-,12-/m0/s1/i19-1

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H23FN4O8

                    

                    
                    

                        
HBD / HBA

                        
6 / 10

                    

                    
                    

                        
Liên kết có thể quay

                        
13

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
31

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Piflufolastat F18 is a fluorine-18 radiolabeled small molecule PSMA-targeted PET imaging agent used for the detection and localization of PSMA-positive lesions in prostate, bladder, and breast cancer staging and restaging. It functions by selectively binding to prostate-specific membrane antigen expressed on tumor cells and tumor neovasculature, enabling precise lesion detection by PET imaging.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Piflufolastat F18 is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL4297334.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 52950901.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.