Succimer
Succimer (DMSA, dimercaptosuccinic acid) is a water-soluble chelating agent used for the treatment of lead poisoning in children and adults, forming stable water-soluble complexes with heavy metals including lead, mercury, and arsenic that are excreted in urine. Unlike older chelators such as EDTA and BAL, succimer is orally bioavailable with lower toxicity and greater selectivity for lead over essential minerals. It is also used as a renal imaging agent (technetium-99m DMSA) for cortical scintigraphy.
分子量
182.2000 g/mol
LogP
0.10
TPSA
76.60 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Provides an essential mineral element required for numerous enzymatic reactions, structural proteins, and physiological processes. Supplementation addresses deficiency states.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Provides an essential mineral element required for numerous enzymatic reactions, structural proteins, and physiological processes. Supplementation addresses deficiency states.
二维结构
Cite this structure
Embed this structure
SMILES
O=C(O)[C@@H](S)[C@@H](S)C(=O)O
InChI
InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+
Molecular Formula
C4H6O4S2
HBD / HBA
4 / 6
可旋转键数
3
重原子数
10
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Succimer (DMSA, dimercaptosuccinic acid) is a water-soluble chelating agent used for the treatment of lead poisoning in children and adults, forming stable water-soluble complexes with heavy metals including lead, mercury, and arsenic that are excreted in urine. Unlike older chelators such as EDTA and BAL, succimer is orally bioavailable with lower toxicity and greater selectivity for lead over essential minerals. It is also used as a renal imaging agent (technetium-99m DMSA) for cortical scintigraphy.
Provides an essential mineral element required for numerous enzymatic reactions, structural proteins, and physiological processes. Supplementation addresses deficiency states.
Yes, Succimer is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201073. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2724354. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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