Succimer
Succimer (DMSA, dimercaptosuccinic acid) is a water-soluble chelating agent used for the treatment of lead poisoning in children and adults, forming stable water-soluble complexes with heavy metals including lead, mercury, and arsenic that are excreted in urine. Unlike older chelators such as EDTA and BAL, succimer is orally bioavailable with lower toxicity and greater selectivity for lead over essential minerals. It is also used as a renal imaging agent (technetium-99m DMSA) for cortical scintigraphy.
Khối lượng phân tử
182,2000 g/mol
LogP
0,10
TPSA
76,60 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Cơ chế tác dụng
Provides an essential mineral element required for numerous enzymatic reactions, structural proteins, and physiological processes. Supplementation addresses deficiency states.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Provides an essential mineral element required for numerous enzymatic reactions, structural proteins, and physiological processes. Supplementation addresses deficiency states.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
O=C(O)[C@@H](S)[C@@H](S)C(=O)O
InChI
InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+
Molecular Formula
C4H6O4S2
HBD / HBA
4 / 6
Liên kết có thể quay
3
Nguyên tử nặng
10
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Succimer (DMSA, dimercaptosuccinic acid) is a water-soluble chelating agent used for the treatment of lead poisoning in children and adults, forming stable water-soluble complexes with heavy metals including lead, mercury, and arsenic that are excreted in urine. Unlike older chelators such as EDTA and BAL, succimer is orally bioavailable with lower toxicity and greater selectivity for lead over essential minerals. It is also used as a renal imaging agent (technetium-99m DMSA) for cortical scintigraphy.
Provides an essential mineral element required for numerous enzymatic reactions, structural proteins, and physiological processes. Supplementation addresses deficiency states.
Yes, Succimer is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201073. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2724354. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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