Talbutal

CHEMBL1200802 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

224.3 g/mol

LogP

1.4

Phase

4

Talbutal is an intermediate-acting barbiturate that acts on GABA-A receptors to enhance chloride ion influx, producing central nervous system depression. It was historically used as a sedative and hypnotic agent for the short-term treatment of insomnia. Due to its high abuse potential, tolerance development, and risk of fatal overdose, it has largely been replaced by safer alternatives.

分子量

224.2600 g/mol

LogP

1.40

TPSA

75.30 Å²

Lipinski 五规则

符合

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

C=CCC1(C(C)CC)C(=O)NC(=O)NC1=O

InChI

InChI=1S/C11H16N2O3/c1-4-6-11(7(3)5-2)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16)

Molecular Formula

C11H16N2O3

HBD / HBA

2 / 3

可旋转键数

4

重原子数

16

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

Talbutal is an intermediate-acting barbiturate that acts on GABA-A receptors to enhance chloride ion influx, producing central nervous system depression. It was historically used as a sedative and hypnotic agent for the short-term treatment of insomnia. Due to its high abuse potential, tolerance development, and risk of fatal overdose, it has largely been replaced by safer alternatives.

Yes, Talbutal is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200802. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 8275. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C11H16N2O3

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.