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Thiothixene

CHEMBL1201 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
443.6 g/mol
LogP
3.8
Phase
4

Thiothixene is a thioxanthene typical antipsychotic that blocks dopamine D2 receptors in the mesolimbic and mesocortical pathways, reducing positive symptoms of psychosis in schizophrenia and related conditions. It also has some affinity for alpha-adrenergic and histamine H1 receptors, contributing to orthostatic hypotension and sedation. Its high potency D2 blockade is associated with a higher risk of extrapyramidal side effects compared to lower-potency antipsychotics.

分子量

443.6000 g/mol

LogP

3.80

TPSA

77.50 Ų

Lipinski 五规则

符合

治疗领域

Schizophrenia Bipolar Disorder Stroke Obesity

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

                    
CN1CCN(CC/C=C2/c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1

                

                

                
                

                    
InChI

                    
InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8-

                

                

                

                    
                    

                        
Molecular Formula

                        
C23H29N3O2S2

                    

                    
                    

                        
HBD / HBA

                        
- / 6

                    

                    
                    

                        
可旋转键数

                        
5

                    

                    
                    
                    

                        
重原子数

                        
30

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
Thiothixene is a thioxanthene typical antipsychotic that blocks dopamine D2 receptors in the mesolimbic and mesocortical pathways, reducing positive symptoms of psychosis in schizophrenia and related conditions. It also has some affinity for alpha-adrenergic and histamine H1 receptors, contributing to orthostatic hypotension and sedation. Its high potency D2 blockade is associated with a higher risk of extrapyramidal side effects compared to lower-potency antipsychotics.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Thiothixene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 941651.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.