Toloxatone
Toloxatone is a selective and reversible monoamine oxidase A (MAO-A) inhibitor that prevents the oxidative deamination of serotonin and norepinephrine, increasing their synaptic concentrations and producing antidepressant effects. It is used for the treatment of depression and has the advantage over irreversible MAO inhibitors of lower risk for tyramine-induced hypertensive crisis (cheese effect) due to its reversibility and selectivity. Its RIMA (reversible inhibitor of MAO-A) profile allows competitive displacement by dietary tyramine, reducing the dietary restrictions required.
分子量
207.2300 g/mol
LogP
1.20
TPSA
49.80 Ų
Lipinski 五规则
符合
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
Cc1cccc(N2CC(CO)OC2=O)c1
InChI
InChI=1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3
Molecular Formula
C11H13NO3
HBD / HBA
1 / 3
可旋转键数
2
重原子数
15
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Toloxatone is a selective and reversible monoamine oxidase A (MAO-A) inhibitor that prevents the oxidative deamination of serotonin and norepinephrine, increasing their synaptic concentrations and producing antidepressant effects. It is used for the treatment of depression and has the advantage over irreversible MAO inhibitors of lower risk for tyramine-induced hypertensive crisis (cheese effect) due to its reversibility and selectivity. Its RIMA (reversible inhibitor of MAO-A) profile allows competitive displacement by dietary tyramine, reducing the dietary restrictions required.
Yes, Toloxatone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL18116. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 34521. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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