Major
Established
描述
Concurrent use of diazepam and oxycodone dramatically increases the risk of fatal respiratory depression, per FDA boxed warning.
机制
Additive CNS depression via GABA-A (diazepam) and mu-opioid receptor (oxycodone) pathways; concurrent use reduces hypoxic ventilatory response.
临床意义
Patients receiving both agents show substantially higher rates of emergency department visits and overdose deaths.
处理措施
Avoid combination or use the lowest possible doses for the shortest duration; co-prescribe naloxone and educate patients.