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Chenodiol

CHEMBL240597 Phase 4 Zugelassen Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
392.6 g/mol
LogP
4.9
Phase
4

A naturally occurring bile acid that dissolves cholesterol gallstones in patients who are poor surgical candidates, by reducing biliary cholesterol saturation. It is also approved for the treatment of cerebrotendinous xanthomatosis, a rare inborn error of bile acid synthesis. Treatment may take months to years and is effective only for radiolucent, cholesterol-rich stones.

Molekularmasse

392,6000 g/mol

LogP

4,90

TPSA

77,80 Ų

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Hyperlipidemia Obesity Type 2 Diabetes Atopic Dermatitis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

                

                

                
                

                    
InChI

                    
InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C24H40O4

                    

                    
                    

                        
HBD / HBA

                        
3 / 4

                    

                    
                    

                        
Rotierbare Bindungen

                        
4

                    

                    
                    
                    

                        
Schwere Atome

                        
28

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Häufig gestellte Fragen

                

                    
                    

                        
                        

                            
A naturally occurring bile acid that dissolves cholesterol gallstones in patients who are poor surgical candidates, by reducing biliary cholesterol saturation. It is also approved for the treatment of cerebrotendinous xanthomatosis, a rare inborn error of bile acid synthesis. Treatment may take months to years and is effective only for radiolucent, cholesterol-rich stones.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Chenodiol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL240597.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 10133.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Medizinischer Haftungsausschluss

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.