Glasdegib

CHEMBL2043437 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

374.4 g/mol

LogP

2.4

Phase

4

A hedgehog pathway inhibitor that blocks Smoothened, a protein involved in the abnormal cell signaling pathway that drives certain leukemias. It is approved in combination with low-dose cytarabine for treating newly diagnosed acute myeloid leukemia in adults who are not eligible for intensive chemotherapy. Blocking this pathway suppresses leukemia stem cell self-renewal.

Molekularmasse

374,4000 g/mol

LogP

2,40

TPSA

96,80 Å²

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

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SMILES

CN1CC[C@@H](NC(=O)Nc2ccc(C#N)cc2)C[C@@H]1c1nc2ccccc2[nH]1

InChI

InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1

Molecular Formula

C21H22N6O

HBD / HBA

3 / 4

Rotierbare Bindungen

3

Schwere Atome

28

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

A hedgehog pathway inhibitor that blocks Smoothened, a protein involved in the abnormal cell signaling pathway that drives certain leukemias. It is approved in combination with low-dose cytarabine for treating newly diagnosed acute myeloid leukemia in adults who are not eligible for intensive chemotherapy. Blocking this pathway suppresses leukemia stem cell self-renewal.

Yes, Glasdegib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2043437. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 25166913. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Struktur

Schnelldaten

Formel: C21H22N6O
Synonyme: 1

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.