Glasdegib

CHEMBL2043437 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

374.4 g/mol

LogP

2.4

Phase

4

A hedgehog pathway inhibitor that blocks Smoothened, a protein involved in the abnormal cell signaling pathway that drives certain leukemias. It is approved in combination with low-dose cytarabine for treating newly diagnosed acute myeloid leukemia in adults who are not eligible for intensive chemotherapy. Blocking this pathway suppresses leukemia stem cell self-renewal.

分子量

374.4000 g/mol

LogP

2.40

TPSA

96.80 Å²

Lipinski 五规则

符合

治疗领域

Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

CN1CC[C@@H](NC(=O)Nc2ccc(C#N)cc2)C[C@@H]1c1nc2ccccc2[nH]1

InChI

InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1

Molecular Formula

C21H22N6O

HBD / HBA

3 / 4

可旋转键数

3

重原子数

28

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A hedgehog pathway inhibitor that blocks Smoothened, a protein involved in the abnormal cell signaling pathway that drives certain leukemias. It is approved in combination with low-dose cytarabine for treating newly diagnosed acute myeloid leukemia in adults who are not eligible for intensive chemotherapy. Blocking this pathway suppresses leukemia stem cell self-renewal.

Yes, Glasdegib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2043437. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 25166913. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C21H22N6O
同义词: 1

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.