Vorinostat
This histone deacetylase (HDAC) inhibitor is used to treat cutaneous T-cell lymphoma (CTCL), a type of cancer affecting the skin, in patients whose disease has progressed or returned during or after two prior treatments. It works by blocking enzymes that regulate gene expression in cancer cells, promoting their death. Common side effects include fatigue, nausea, and blood clots, and patients need regular monitoring of blood counts and electrolytes.
Molekularmasse
264,3200 g/mol
LogP
1,90
TPSA
78,40 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.
2D-Struktur
Cite this structure
Embed this structure
SMILES
O=C(CCCCCCC(=O)Nc1ccccc1)NO
InChI
InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
Molecular Formula
C14H20N2O3
HBD / HBA
3 / 3
Rotierbare Bindungen
8
Schwere Atome
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
This histone deacetylase (HDAC) inhibitor is used to treat cutaneous T-cell lymphoma (CTCL), a type of cancer affecting the skin, in patients whose disease has progressed or returned during or after two prior treatments. It works by blocking enzymes that regulate gene expression in cancer cells, promoting their death. Common side effects include fatigue, nausea, and blood clots, and patients need regular monitoring of blood counts and electrolytes.
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.
Yes, Vorinostat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL98. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5311. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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