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Vorinostat

CHEMBL98 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
264.3 g/mol
LogP
1.9
Phase
4

This histone deacetylase (HDAC) inhibitor is used to treat cutaneous T-cell lymphoma (CTCL), a type of cancer affecting the skin, in patients whose disease has progressed or returned during or after two prior treatments. It works by blocking enzymes that regulate gene expression in cancer cells, promoting their death. Common side effects include fatigue, nausea, and blood clots, and patients need regular monitoring of blood counts and electrolytes.

Khối lượng phân tử

264,3200 g/mol

LogP

1,90

TPSA

78,40 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Rheumatoid Arthritis Epilepsy Schizophrenia Melanoma Lymphoma Breast Cancer HIV/AIDS Heart Failure Prostate Cancer Colorectal Cancer Leukemia

Cơ chế tác dụng

Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=C(CCCCCCC(=O)Nc1ccccc1)NO

                

                

                
                

                    
InChI

                    
InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H20N2O3

                    

                    
                    

                        
HBD / HBA

                        
3 / 3

                    

                    
                    

                        
Liên kết có thể quay

                        
8

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
This histone deacetylase (HDAC) inhibitor is used to treat cutaneous T-cell lymphoma (CTCL), a type of cancer affecting the skin, in patients whose disease has progressed or returned during or after two prior treatments. It works by blocking enzymes that regulate gene expression in cancer cells, promoting their death. Common side effects include fatigue, nausea, and blood clots, and patients need regular monitoring of blood counts and electrolytes.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Provides essential ions for maintaining fluid balance, nerve conduction, muscle contraction, and acid-base homeostasis. Supplementation corrects electrolyte imbalances.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Vorinostat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL98.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5311.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.