PTGS2 (Cyclooxygenase-2)
PTGS2
Inducible cyclooxygenase isoform upregulated during inflammation and pain signaling.
Funktion
Catalyzes prostaglandin H2 synthesis at sites of inflammation. Primary target of NSAIDs and selective COX-2 inhibitors (coxibs).
Arzneimittel, die auf dieses Target wirken
| Arzneimittel | Wirkung | Primär |
|---|---|---|
| Montelukast | Antagonist | Ja |
| Naproxen | Inhibitor | Ja |
| Celecoxib | Inhibitor | Ja |
| Ibuprofen | Inhibitor | Ja |
| Doxycycline | Inhibitor | Ja |
| Hydroxychloroquine | Inhibitor | Ja |
| Allopurinol | Inhibitor | Ja |
| Acetaminophen | Inhibitor | Ja |
| Aspirin | Inhibitor | — |
| Prednisone | Inhibitor | — |
| Dexamethasone | Inhibitor | — |
| Methotrexate | Inhibitor | — |