HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
Funktion
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
Arzneimittel, die auf dieses Target wirken
| Arzneimittel | Wirkung | Primär |
|---|---|---|
| Atorvastatin | Inhibitor | Ja |
| Simvastatin | Inhibitor | Ja |
| Rosuvastatin | Inhibitor | Ja |
| Pravastatin | Inhibitor | Ja |