Chlordiazepoxide Hydrochloride
The hydrochloride salt form of chlordiazepoxide is the standard oral and injectable preparation used for anxiety and alcohol withdrawal management. It shares the same benzodiazepine pharmacology as the parent compound. Risk of respiratory depression increases when combined with other CNS depressants such as opioids or alcohol.
Molecular Weight
336.2000 g/mol
TPSA
48.20 Ų
Therapeutic Areas
Mechanism of Action
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …
2D Structure
Cite this structure
Embed this structure
SMILES
CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C1.Cl
InChI
InChI=1S/C16H14ClN3O.ClH/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15;/h2-9H,10H2,1H3,(H,18,19);1H
Molecular Formula
C16H15Cl2N3O
HBD / HBA
2 / 3
Rotatable Bonds
1
Heavy Atoms
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
The hydrochloride salt form of chlordiazepoxide is the standard oral and injectable preparation used for anxiety and alcohol withdrawal management. It shares the same benzodiazepine pharmacology as the parent compound. Risk of respiratory depression increases when combined with other CNS depressants such as opioids or alcohol.
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Yes, Chlordiazepoxide Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200703. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9916. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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