Rufinamide

CHEMBL1201754 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

238.2 g/mol

LogP

0.7

Phase

4

An anticonvulsant used primarily as adjunctive therapy for seizures associated with Lennox-Gastaut syndrome, a severe childhood epilepsy disorder. It works by modulating sodium channel activity in neurons to reduce the frequency and severity of seizures.

Molecular Weight

238.1900 g/mol

LogP

0.70

TPSA

73.80 Å²

Lipinski RO5

Pass

Therapeutic Areas

Chronic Pain Epilepsy Generalized Anxiety Disorder Pain Management

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

NC(=O)c1cn(Cc2c(F)cccc2F)nn1

InChI

InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)

Molecular Formula

C10H8F2N4O

HBD / HBA

1 / 5

Rotatable Bonds

3

Heavy Atoms

17

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

An anticonvulsant used primarily as adjunctive therapy for seizures associated with Lennox-Gastaut syndrome, a severe childhood epilepsy disorder. It works by modulating sodium channel activity in neurons to reduce the frequency and severity of seizures.

Yes, Rufinamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201754. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 129228. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C10H8F2N4O
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.