Amitriptyline
A tricyclic antidepressant that raises levels of serotonin and norepinephrine in the brain by preventing their reabsorption into nerve cells. Beyond depression, it is widely used off-label for chronic pain, nerve pain, and sleep disturbances.
Peso molecular
277,4000 g/mol
LogP
5,00
TPSA
3,20 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
CN(C)CCC=C1c2ccccc2CCc2ccccc21
InChI
InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
Molecular Formula
C20H23N
HBD / HBA
- / 1
Enlaces Rotables
3
Átomos Pesados
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A tricyclic antidepressant that raises levels of serotonin and norepinephrine in the brain by preventing their reabsorption into nerve cells. Beyond depression, it is widely used off-label for chronic pain, nerve pain, and sleep disturbances.
Yes, Amitriptyline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL629. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2160. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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