Monoclonal Antibody (mAb)
mAbA laboratory-produced antibody engineered to bind a single specific epitope on a target antigen. Monoclonal antibodies are produced using hybridoma technology or recombinant methods and are classified by origin: murine (-omab), chimeric (-ximab), humanized (-zumab), or fully human (-umab). They represent the fastest-growing drug class, with applications in oncology, autoimmunity, and infectious diseases.
Ejemplos
- Rituximab — anti-CD20 (non-Hodgkin lymphoma, rheumatoid arthritis)
- Adalimumab — anti-TNF-alpha (rheumatoid arthritis, Crohn's disease)
- Pembrolizumab — anti-PD-1 (multiple cancers)
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A laboratory-produced antibody engineered to bind a single specific epitope on a target antigen. Monoclonal antibodies are produced using hybridoma technology or recombinant methods and are classified by origin: murine …