Protein Binding
The reversible binding of drugs to plasma proteins (primarily albumin and alpha-1-acid glycoprotein). Only unbound (free) drug is pharmacologically active and available for distribution and elimination.
Exemples
- Warfarin 99% bound
- Gentamicin <10% bound
- Displacement interactions (phenytoin + valproate)
Le saviez-vous ?
The reversible binding of drugs to plasma proteins (primarily albumin and alpha-1-acid glycoprotein). Only unbound (free) drug is pharmacologically active and available for distribution and elimination.