Protein Binding
The reversible binding of drugs to plasma proteins (primarily albumin and alpha-1-acid glycoprotein). Only unbound (free) drug is pharmacologically active and available for distribution and elimination.
예시
- Warfarin 99% bound
- Gentamicin <10% bound
- Displacement interactions (phenytoin + valproate)
알고 계셨나요?
The reversible binding of drugs to plasma proteins (primarily albumin and alpha-1-acid glycoprotein). Only unbound (free) drug is pharmacologically active and available for distribution and elimination.