ABCB1 (P-glycoprotein)
ABCB1
ATP-dependent efflux transporter limiting oral bioavailability and CNS penetration.
Fungsi
Pumps substrates out of cells at the blood-brain barrier and intestinal epithelium.
Obat yang Bekerja pada Target Ini
| Obat | Aksi | Utama |
|---|---|---|
| Carbamazepine | Inducer | — |
| Cyclosporine | Inhibitor | — |
| Tacrolimus | Substrate | — |
| Atorvastatin | Substrate | — |
| Dabigatran | Substrate | — |
| Rivaroxaban | Substrate | — |
| Empagliflozin | Substrate | — |
| Morphine | Substrate | — |
| Colchicine | Substrate | — |
| Digoxin | Substrate | — |