Amoxicillin
A broad-spectrum penicillin-type antibiotic that works by interfering with bacteria's ability to build their cell walls, causing them to burst and die. It is one of the most widely prescribed antibiotics for respiratory, ear, and urinary tract infections.
分子量
365.4050 g/mol
LogP
-2.00
TPSA
158.00 Ų
リピンスキーの五則
適合
治療領域
薬物分類
作用機序
Inhibits bacterial cell wall synthesis by binding to PBPs.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial cell wall synthesis by binding to PBPs.
2D構造
Cite this structure
Embed this structure
SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O
InChI
InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1
Molecular Formula
C16H19N3O5S
HBD / HBA
4 / 7
回転可能結合数
4
重原子数
25
Amoxicillin may slightly potentiate warfarin by reducing gut flora that synthesize vitamin K2, though the effect is generally small and inconsistent.
Amoxicillin can reduce the renal clearance of methotrexate by inhibiting tubular secretion, increasing methotrexate plasma levels and risk of toxicity.
The combination of allopurinol and amoxicillin is associated with a markedly increased incidence of skin rashes (primarily maculopapular), though the rash is usually non-severe and reversible.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A broad-spectrum penicillin-type antibiotic that works by interfering with bacteria's ability to build their cell walls, causing them to burst and die. It is one of the most widely prescribed antibiotics for respiratory, ear, and urinary tract infections.
Inhibits bacterial cell wall synthesis by binding to PBPs.
Key pharmacokinetic parameters for Amoxicillin: Half-life: 1-1.5 hours.
Yes, Amoxicillin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1082. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 33613. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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