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Amoxicillin

CHEMBL1082 Phase 4 Đã phê duyệt Small molecule
Half-Life
1-1.5 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
365.4 g/mol
LogP
-2.0
Phase
4

A broad-spectrum penicillin-type antibiotic that works by interfering with bacteria's ability to build their cell walls, causing them to burst and die. It is one of the most widely prescribed antibiotics for respiratory, ear, and urinary tract infections.

Khối lượng phân tử

365,4050 g/mol

LogP

-2,00

TPSA

158,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Cardiovascular Disease Respiratory Disease Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Asthma Chronic Obstructive Pulmonary Disease Immunology Parkinson's Disease Epilepsy Generalized Anxiety Disorder Infectious Disease Gastroesophageal Reflux Disease Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Deep Vein Thrombosis / Pulmonary Embolism Obesity Lymphoma Type 2 Diabetes Breast Cancer Chronic Pain Malaria Tuberculosis Atrial Fibrillation Prostate Cancer Colorectal Cancer Leukemia

Phân loại thuốc

J — J - Antiinfectives for Systemic Use

Cơ chế tác dụng

Inhibits bacterial cell wall synthesis by binding to PBPs.

Pharmacokinetics (PK)

Half-Life 1-1.5 hours

Pharmacodynamics (PD)

Cơ chế

Inhibits bacterial cell wall synthesis by binding to PBPs.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H19N3O5S

                    

                    
                    

                        
HBD / HBA

                        
4 / 7

                    

                    
                    

                        
Liên kết có thể quay

                        
4

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
25

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            ABCB1 (P-glycoprotein)
                            Substrate
                        

                        
                        Primary Target
                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Minor


                            
                                Amoxicillin + Warfarin
                            
                        

                        
                        
Amoxicillin may slightly potentiate warfarin by reducing gut flora that synthesize vitamin K2, though the effect is generally small and inconsistent.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Amoxicillin + Methotrexate
                            
                        

                        
                        
Amoxicillin can reduce the renal clearance of methotrexate by inhibiting tubular secretion, increasing methotrexate plasma levels and risk of toxicity.

                        
                    
                    
                    
                        

                            

  
  Minor


                            
                                Amoxicillin + Allopurinol
                            
                        

                        
                        
The combination of allopurinol and amoxicillin is associated with a markedly increased incidence of skin rashes (primarily maculopapular), though the rash is usually non-severe and reversible.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A broad-spectrum penicillin-type antibiotic that works by interfering with bacteria's ability to build their cell walls, causing them to burst and die. It is one of the most widely prescribed antibiotics for respiratory, ear, and urinary tract infections.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits bacterial cell wall synthesis by binding to PBPs.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Amoxicillin: Half-life: 1-1.5 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Amoxicillin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            
            

                
                
                    ADME Journey →
                
                
                
            

            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Azithromycin
                            Small molecule
                        
                        
                        
                            Ciprofloxacin
                            Small molecule
                        
                        
                        
                            Doxycycline
                            Small molecule
                        
                        
                        
                            Metronidazole
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1082.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 33613.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.