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Erlotinib Hydrochloride

CHEMBL1079742 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
429.9 g/mol
LogP
—
Phase
4

The hydrochloride salt form of erlotinib, this targeted cancer drug blocks the EGFR signaling pathway to slow the growth of EGFR-mutated tumors. The hydrochloride salt formulation is used in standard oral capsules.

分子量

429.9000 g/mol

TPSA

74.70 Ų

治療領域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Cardiovascular Disease Age-Related Macular Degeneration Respiratory Disease Pain Management Non-Small Cell Lung Cancer Chronic Obstructive Pulmonary Disease Alzheimer's Disease Parkinson's Disease Infectious Disease Melanoma Gastroesophageal Reflux Disease Inflammatory Bowel Disease Psoriasis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Lymphoma Breast Cancer Chronic Pain Hepatitis C Prostate Cancer Colorectal Cancer Leukemia

作用機序

Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

機序

Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H24ClN3O4

                    

                    
                    

                        
HBD / HBA

                        
2 / 7

                    

                    
                    

                        
回転可能結合数

                        
11

                    

                    
                    
                    

                        
重原子数

                        
30

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
The hydrochloride salt form of erlotinib, this targeted cancer drug blocks the EGFR signaling pathway to slow the growth of EGFR-mutated tumors. The hydrochloride salt formulation is used in standard oral capsules.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Erlotinib Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1079742.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 176871.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.