CYP2D6 (Cytochrome P450 2D6)
CYP2D6
Polymorphic CYP enzyme metabolizing ~25% of drugs including many psychotropics and opioids.
기능
Highly polymorphic with poor to ultra-rapid metabolizer phenotypes. Key pharmacogenomic target.
이 표적에 작용하는 약물
| 약물 | 작용 | 주요 |
|---|---|---|
| Celecoxib | Inhibitor | — |
| Sertraline | Inhibitor | — |
| Duloxetine | Inhibitor | — |
| Bupropion | Inhibitor | — |
| Fluoxetine | Inhibitor | — |
| Tamoxifen | Substrate | — |
| Oxycodone | Substrate | — |
| Tramadol | Substrate | — |
| Metoprolol | Substrate | — |