HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
기능
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
이 표적에 작용하는 약물
| 약물 | 작용 | 주요 |
|---|---|---|
| Atorvastatin | Inhibitor | 예 |
| Simvastatin | Inhibitor | 예 |
| Rosuvastatin | Inhibitor | 예 |
| Pravastatin | Inhibitor | 예 |