HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
İşlev
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
Bu Hedefe Etki Eden İlaçlar
| İlaç | Etki | Birincil |
|---|---|---|
| Atorvastatin | Inhibitor | Evet |
| Simvastatin | Inhibitor | Evet |
| Rosuvastatin | Inhibitor | Evet |
| Pravastatin | Inhibitor | Evet |