HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
الوظيفة
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
الأدوية التي تؤثر على هذا الهدف
| الدواء | الفعل | أساسي |
|---|---|---|
| Atorvastatin | Inhibitor | نعم |
| Simvastatin | Inhibitor | نعم |
| Rosuvastatin | Inhibitor | نعم |
| Pravastatin | Inhibitor | نعم |