CYP2D6 (Cytochrome P450 2D6)
CYP2D6
Polymorphic CYP enzyme metabolizing ~25% of drugs including many psychotropics and opioids.
الوظيفة
Highly polymorphic with poor to ultra-rapid metabolizer phenotypes. Key pharmacogenomic target.
الأدوية التي تؤثر على هذا الهدف
| الدواء | الفعل | أساسي |
|---|---|---|
| Bupropion | Inhibitor | نعم |
| Metronidazole | Inhibitor | نعم |
| Duloxetine | Inhibitor | — |
| Fluoxetine | Inhibitor | — |
| Omeprazole | Inhibitor | — |
| Celecoxib | Inhibitor | — |
| Sertraline | Inhibitor | — |
| Fluconazole | Inhibitor | — |
| Valproic Acid | Inhibitor | — |
| Ibuprofen | Substrate | — |
| Tamoxifen | Substrate | — |
| Clopidogrel | Substrate | — |
| Oxycodone | Substrate | — |
| Tramadol | Substrate | — |
| Metoprolol | Substrate | — |
| Warfarin | Substrate | — |