HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
功能
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
作用于该靶点的药物
| 药物 | 作用 | 主要 |
|---|---|---|
| Atorvastatin | Inhibitor | 是 |
| Pravastatin | Inhibitor | 是 |
| Rosuvastatin | Inhibitor | 是 |
| Simvastatin | Inhibitor | 是 |