PTGS2 (Cyclooxygenase-2)
PTGS2
Inducible cyclooxygenase isoform upregulated during inflammation and pain signaling.
功能
Catalyzes prostaglandin H2 synthesis at sites of inflammation. Primary target of NSAIDs and selective COX-2 inhibitors (coxibs).
作用于该靶点的药物
| 药物 | 作用 | 主要 |
|---|---|---|
| Montelukast | Antagonist | 是 |
| Naproxen | Inhibitor | 是 |
| Celecoxib | Inhibitor | 是 |
| Ibuprofen | Inhibitor | 是 |
| Doxycycline | Inhibitor | 是 |
| Hydroxychloroquine | Inhibitor | 是 |
| Allopurinol | Inhibitor | 是 |
| Acetaminophen | Inhibitor | 是 |
| Aspirin | Inhibitor | — |
| Prednisone | Inhibitor | — |
| Dexamethasone | Inhibitor | — |
| Methotrexate | Inhibitor | — |