Rosuvastatin
A potent statin medication used to lower LDL cholesterol and triglycerides while raising HDL cholesterol, significantly reducing the risk of heart attack, stroke, and other cardiovascular events. It is generally well-tolerated and effective at low doses, making it one of the most widely prescribed cholesterol-lowering medications.
分子量
481.5390 g/mol
LogP
1.60
TPSA
149.00 Ų
Lipinski 五规则
符合
治疗领域
药物分类
作用机制
Competitive inhibitor of HMG-CoA reductase.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitive inhibitor of HMG-CoA reductase.
二维结构
Cite this structure
Embed this structure
SMILES
CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1/C=C/[C@@H](O)C[C@@H](O)CC(=O)O
InChI
InChI=1S/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17-/m1/s1
Molecular Formula
C22H28FN3O6S
HBD / HBA
3 / 10
可旋转键数
10
重原子数
33
Rosuvastatin increases warfarin plasma concentrations through inhibition of CYP2C9, potentially leading to supratherapeutic INR values.
Rosuvastatin and colchicine share BCRP transporter-mediated elimination; colchicine may weakly increase rosuvastatin exposure, and both carry myotoxic potential that could be additive.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A potent statin medication used to lower LDL cholesterol and triglycerides while raising HDL cholesterol, significantly reducing the risk of heart attack, stroke, and other cardiovascular events. It is generally well-tolerated and effective at low doses, making it one of the most widely prescribed cholesterol-lowering medications.
Competitive inhibitor of HMG-CoA reductase.
Key pharmacokinetic parameters for Rosuvastatin: Half-life: 19 hours.
Yes, Rosuvastatin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1496. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 446157. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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