HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
Функция
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
Препараты, действующие на данную мишень
| Препарат | Действие | Первичный |
|---|---|---|
| Atorvastatin | Inhibitor | Да |
| Simvastatin | Inhibitor | Да |
| Rosuvastatin | Inhibitor | Да |
| Pravastatin | Inhibitor | Да |