HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
Função
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
Medicamentos que Atuam neste Alvo
| Medicamento | Ação | Primário |
|---|---|---|
| Atorvastatin | Inhibitor | Sim |
| Simvastatin | Inhibitor | Sim |
| Rosuvastatin | Inhibitor | Sim |
| Pravastatin | Inhibitor | Sim |