HMGCR (HMG-CoA Reductase)
HMGCR
Rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis.
Fonction
Catalyzes conversion of HMG-CoA to mevalonate. Statins competitively inhibit this enzyme, reducing hepatic cholesterol synthesis.
Médicaments agissant sur cette cible
| Médicament | Action | Principal |
|---|---|---|
| Atorvastatin | Inhibitor | Oui |
| Simvastatin | Inhibitor | Oui |
| Rosuvastatin | Inhibitor | Oui |
| Pravastatin | Inhibitor | Oui |