Cetirizine
A second-generation antihistamine that selectively blocks peripheral H1 receptors to relieve symptoms of allergic rhinitis, chronic urticaria, and other allergic conditions. Unlike first-generation antihistamines, it has low CNS penetration, resulting in less sedation in most patients. It is available over the counter and is one of the most widely used allergy medications worldwide.
Peso Molecular
388,8900 g/mol
LogP
1,70
TPSA
53,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Classes de Medicamentos
Mecanismo de Ação
Second-generation H1 antihistamine.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Second-generation H1 antihistamine.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
InChI
InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)
Molecular Formula
C21H25ClN2O3
HBD / HBA
1 / 5
Ligações Rotacionáveis
8
Átomos Pesados
27
Concurrent use of cetirizine and oxycodone may produce additive CNS and respiratory depression, increasing the risk of sedation and, at higher doses, respiratory compromise.
Cetirizine may add to morphine-induced CNS depression, increasing sedation and potentially enhancing respiratory depression, particularly with higher doses of either agent.
Cetirizine has mild CNS depressant properties that can be additive with the sedative effects of alprazolam, increasing the risk of excessive sedation, psychomotor impairment, and respiratory depression.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A second-generation antihistamine that selectively blocks peripheral H1 receptors to relieve symptoms of allergic rhinitis, chronic urticaria, and other allergic conditions. Unlike first-generation antihistamines, it has low CNS penetration, resulting in less sedation in most patients. It is available over the counter and is one of the most widely used allergy medications worldwide.
Second-generation H1 antihistamine.
Key pharmacokinetic parameters for Cetirizine: Half-life: 6.5-10 hours.
Yes, Cetirizine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1000. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2678. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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