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Loratadine

CHEMBL998 Phase 4 Aprovado Small molecule
Half-Life
8 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
382.9 g/mol
LogP
5.2
Phase
4

A second-generation, non-sedating antihistamine, loratadine blocks peripheral H1 histamine receptors to reduce sneezing, runny nose, and itching without causing significant drowsiness. It treats allergic rhinitis and chronic hives. Sold over the counter as Claritin and Alavert, the compound has the formula C22H23ClN2O2 and its minimal central nervous system penetration distinguishes it from older allergy medications.

A second-generation, non-sedating antihistamine used to relieve allergic rhinitis and hives (urticaria). It blocks peripheral H1 histamine receptors to reduce sneezing, runny nose, and itching without causing significant drowsiness.

Peso Molecular

382,8800 g/mol

LogP

5,20

TPSA

42,40 Ų

Regra dos 5 de Lipinski

Aprovado

Classes de Medicamentos

R — R - Respiratory System

Mecanismo de Ação

Second-generation H1 antihistamine with minimal CNS effects.

Pharmacokinetics (PK)

Half-Life 8 hours

Pharmacodynamics (PD)

Mecanismo

Second-generation H1 antihistamine with minimal CNS effects.

Estrutura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H23ClN2O2

                    

                    
                    

                        
HBD / HBA

                        
- / 3

                    

                    
                    

                        
Ligações Rotacionáveis

                        
2

                    

                    
                    
                    

                        
Átomos Pesados

                        
27

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            HRH1 (Histamine H1 Receptor)
                            Antagonist
                        

                        
                        Primary Target
                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Minor


                            
                                Loratadine + Fluconazole
                            
                        

                        
                        
Fluconazole inhibits CYP3A4-mediated metabolism of loratadine, modestly increasing loratadine plasma concentrations; however, loratadine's poor CNS penetration limits the clinical consequence.

                        
                    
                    
                    
                        

                            

  
  Minor


                            
                                Loratadine + Azithromycin
                            
                        

                        
                        
Azithromycin is a weak CYP3A4 inhibitor that can modestly raise loratadine plasma levels; the clinical impact is minimal given loratadine's wide therapeutic index and low cardiac risk.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
A second-generation, non-sedating antihistamine used to relieve allergic rhinitis and hives (urticaria). It blocks peripheral H1 histamine receptors to reduce sneezing, runny nose, and itching without causing significant drowsiness.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Second-generation H1 antihistamine with minimal CNS effects.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Loratadine: Half-life: 8 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Loratadine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
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                            Small molecule
                        
                        
                        
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                            Small molecule
                        
                        
                        
                            Cetirizine
                            Small molecule
                        
                        
                        
                            Diphenhydramine
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL998.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3957.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.